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Areas of Focus
The Division's clinical activities include:
- Inpatient Consultation Service
- Outpatient longitudinal care, hemodialysis and peritoneal dialysis for over 700 dialysis patients
- One of the largest nocturnal dialysis facilities in the country
- Renal replacement therapies (intermittent hemodialysis, continuous ambulatory peritoneal dialysis and variations, continuous renal replacement therapy and apheresis)
- Diagnosis and management related to: acute renal failure, electrolyte and acid-base abnormalities, hypertension, renal/kidney/pancreas/liver transplantation, parenchymal renal disease, genetic renal diseases (e.g., polycystic kidney disease, Alport's syndrome), and vascular access complications
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Basic Sciences
The Division of Nephrology and the newly-established Center for Immunity, Inflammation and Regenerative Medicine maintain an active research program funded by NIH grants to support basic and translation research in:
- immune response to acute kidney injury
- novel therapies for kidney disease
- diabetic nephropathy
- microbubbles for assessing kidney function
- lupus nephritis
- naturally occurring IgM autoantibodies in transplantation and HIV
- natural killer cells in viral infections
- T regulatory cells in autoimmune diseases
- dendritic cells in inflammatory diseases
- Goodpasture syndrome
- allograft rejection
- renin-angiotensin system in vascular biology
T32 Training Grant
An NIH training grant on "Kidney Disease and Inflammation" focuses on training postdoctoral fellows in research. Twenty-nine faculty from various disciplines in the School of Medicine serve as faculty mentors.
Clinical Sciences
Clinical research activities under the direction of Dr. W. Kline Bolton, Director of the Nephrology Clinical Research Center, cover a broad range of topics funded by NIH and industry. The NCRC is housed next to the Division of Nephrology and consists of a full complement of administrative and clinical staff to carry out funded projects.
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Expanding Patient Volume
Established in 1967, the UVa kidney transplant program is one of the busiest in Virginia and the region. More than 1,500 kidney recipients, including high-risk candidates, have received their care here.
We've seen dramatic growth over the past four years:
- from 65 to 110 renal transplants per year(about half living-donor)
- pancreas transplant volumes of 15 to 20 per year
- 20% growth in two years across all abdominal transplant programs, with sustained growth anticipated
Innovative Programs
Our transplant programs are multidisciplinary, with combined medical-surgical clinics and inpatient services.
The renal program includes innovative translational research protocols and programs for ABO and cross-match incompatible transplants, altruistic live donation, and donor advocacy.
An islet transplant program is underway and an FDA-approved islet isolation facility is operational.
An active clinical research program in collaboration with pharmaceutical companies is also available.
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Fellowship Training
The fellowship training program, under the direction of Dr. Mitchell Rosner, accepts 4 clinical fellows each year. We offer two pathways to meet candidates' goals:
Our Research Track is now funded by an NIH T32 grant. Candidates can pursue training along several pathways to achieve the goal of becoming an independent investigator:
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Basic and Translational Research
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Clinical Investigation
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Basic Translational Research or Clinical Investigation, with pursuit of an advanced degree
PostDoctoral Training
Our postdoctoral training program is designed to prepare postdoctoral fellows for academic and/or clinical careers in the disciplines of nephrology and hypertension.
We offer training opportunities in Clinical Nephrology and in Renal and Hypertension Research, both supported by an NIH training grant.
Training in patient-oriented research is available through the Robert Wood Johnson Clinical Scholars Program. Fellows also have the opportunity to participate in the Investigative Medicine Program leading to a Ph.D. in either laboratory or patient-oriented research.
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